Posts

02/13/2025


In order to better accelerate the transition from traditional trade to cross-border e-commerce, a cross-border e-commerce transportation route optimization model was designed in the context of the prevention and control of new crown pneumonia. Against the background of the new coronavirus pneumonia, through the analysis and research of the current situation of domestic and foreign e-commerce logistics, optimize the cross-border e-commerce logistics distribution model, establish an environmental model, and use efficient search algorithms to search for walking paths that meet environmental requirements. Based on the Dijkstra algorithm model of demand, and based on the linear relationship between demand and delivery distance, an optimal route selection model is established to select the optimal route with the shortest total travel distance. The simulation results show that the cross-border e-commerce transportation time of this model is within 13 h, which is shorter than that of the traditional model. The search efficiency of the optimal route for cross-border e-commerce transportation is higher, and the time for cross-border e-commerce transportation is shorter.Some individuals experience the feeling that they have become a person they had not anticipated. The life path they had expected to take is not consonant with the one they are taking in reality. This perception of "off-course" in identity and self-direction is referred to as derailment. Although previous studies have postulated and demonstrated that derailment causes a low level of well-being, no studies have examined its existence and effect across cultures. We hypothesized that East Asians (Japanese) are less vulnerable to feeling derailed than North Americans (Canadians/Americans), and that those Japanese who feel derailed do not necessarily experience long-term damage to their well-being. Two correlational studies and one longitudinal study with a one-year interval supported these hypotheses and also demonstrated metric invariance of the Derailment Scale between countries. We discuss that these findings may be explained by East Asian's dialectical thinking, in which the perception of one's life direction is flexible.
The online version contains supplementary material available at (10.1007/s10902-021-00375-4).
The online version contains supplementary material available at (10.1007/s10902-021-00375-4).Intramolecular interactions within a protein are key in maintaining protein tertiary structure and understanding how proteins function. Ion mobility-mass spectrometry (IM-MS) has become a widely used approach in structural biology since it provides rapid measurements of collision cross sections (CCS), which inform on the gas-phase conformation of the biomolecule under study. Gas-phase ion/ion reactions target amino acid residues with specific chemical properties and the modified sites can be identified by MS. In this study, electrostatically reactive, gas-phase ion/ion chemistry and IM-MS are combined to characterize the structural changes between ubiquitin electrosprayed from aqueous and denaturing conditions. The electrostatic attachment of sulfo-NHS acetate to ubiquitin via ion/ion reactions and fragmentation by electron-capture dissociation (ECD) provide the identification of the most accessible protonated sites within ubiquitin as the sulfonate group forms an electrostatic complex with accessible protonated side chains. The protonated sites identified by ECD from the different solution conditions are distinct and, in some cases, reflect the disruption of interactions such as salt bridges that maintain the native protein structure. This agrees with previously published literature demonstrating that a high methanol concentration at low pH causes the structure of ubiquitin to change from a native (N) state to a more elongated A state. Results using gas-phase, electrostatic cross-linking reagents also point to similar structural changes and further confirm the role of methanol and acid in favoring a more unfolded conformation. https://www.selleckchem.com/products/napabucasin.html Since cross-linking reagents have a distance constraint for the two reactive sites, the data is valuable in guiding computational structures generated by molecular dynamics. The research presented here describes a promising strategy that can detect subtle changes in the local environment of targeted amino acid residues to inform on changes in the overall protein structure.Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used over-the-counter drugs and their uncontrolled disposal is a significant environmental concern. Although their fluorescent sensing is a desirable method of detection for its sensitivity and simplicity, the structural similarity of the drugs makes the design of selective sensors highly challenging. A thiourea-based fluorescent functional monomer was identified in this work to enable highly efficient synthesis of molecularly imprinted nanoparticle (MINP) sensors for NSAIDs such as Indomethacin or Tolmetin. Micromolar binding affinities were obtained in aqueous solution, with binding selectivities comparable to those reported for polyclonal antibodies. The detection limit was ~50 ng/mL in aqueous solution, and common carboxylic acids such as acetic acid, benzoic acid, and citric acid showed negligible interference.Most older adults will eventually stop driving, but few engage in planning for driving retirement. This study assessed whether driving stress, enjoyment, confidence, concerning driving events, and assessment of driving alternatives influence planning. Demographic factors were also included. Data were collected via a mailed transportation survey, with a final sample of 551 older adults who currently drive. Linear regression analyses revealed that more driving retirement planning was associated with greater driving stress, less driving confidence, and a more positive view of driving alternatives. Driving enjoyment and recent concerning driving events were not significantly related. Among the control variables, race and income were significantly related to planning, suggesting that lower income and identifying as Black race were associated with more planning. Gender only approached significance, suggesting that females may plan more than males. Overall, these findings suggest that more driving retirement planning is warranted.

02/13/2025


The purpose of this paper is to analyze the morphological variation of human populations that inhabited the southern Andes (Mendoza city, Argentina) during 16th to 19th centuries. That period represents an encounter of several distinctive populations inhabiting the same area Europeans, descendants from Europeans (criollos), Africans, and Native Americans. In this paper, we study the shape changes of the cranial base, cranial vault, facial skeleton, and mandible to evaluate if the craniofacial variation differs in relation to the colonial periods and burial areas. For this, we analyzed 44 skulls from four colonial temples of the Foundational Area of Mendoza, and 36 prehistoric ones as a comparative sample. A total of 84 3D anatomical landmarks were registered with a Microscribe G2X. First, we explored the morphological changes by chronological period through a Principal Component Analysis, and then we calculated Mahalanobis distances among the individuals from different chronological periods. Second, we evaluated the morphological variation of the colonial subsample according to chronological period, archaeological site, and burial area. https://www.selleckchem.com/products/az-3146.html For this, we conducted a Principal Component Analysis and a MANOVA. We represent the morphological changes by Wireframes that show the main variation along PC1 and PC2. The results obtained showed morphological differences in the cranial base and facial skeleton of the individuals from different chronological periods, while the cranial base and mandible vary when comparing individuals from different burial areas. We conclude that the colonial society was highly diverse in terms of biological and cultural variation, and that there were differential dietary patterns among them.Discrete, small, roundish lesions of localized porous bone can be occasionally seen in the craniofacial skeleton. Such lesions are rarely mentioned and only occur as an incidental discovery being assigned to plenty of diagnoses. As an example, such multiple small lesions of the facial skeleton in a well-preserved skeleton of a 40-60 year old male of the Hunno-Sarmatian Period from Kazakhstan, are discussed. Some of the lesions were examined by digital microscopy, plain radiography, and plain and polarizing microscopy. Considering possible differential diagnoses of vascular, traumatic, inflammatory/reactive, metabolic, and neoplastic entities, as well as developmental conditions, its microscopic characteristics point to a fibro-osseous process. This paper intends to open a discussion on the diagnosis of such lesions, which have been relatively neglected in previous research.Objectives Torus Palatinus (TP) is a bony projection located on the oral surface of the hard palate. The trait is typically benign, has an unknown etiology, and varies widely in phenotypic expression. Prior studies suggest differences in TP prevalence by sex and ancestry, but the reported rates vary, even within a single ancestral group. We assessed the prevalence of TP and its association with palatal shape in a large multi-ethnic cohort of normal individuals. Methodology 1102 adults were included (625 with European ancestry, 377 with West African anscestry, and 100 with East Asian ancestry). 3D digital dental casts were obtained and rated. TP frequencies were compared between sexes and/or ethnicities using Chi-squared tests. Dental cast models were then landmarked, and canonical variates analysis was performed to test for shape differences between those with and without TP. Results Females had a significantly higher rate of TP than males across all three ancestral groups (p≤0.004). In males, no significant differences were found among ethnicities. Ancestral differences in TP frequency were driven by females, with East Asians having the highest rate (34.69%), followed by Europeans (24.88%) and West Africans (15.22%). Shape differences were found only in Asians and Africans, indicated a shorter and wider palate in presence of TP. Conclusions Ethnic differences in TP frequency were present only in females. Further, females have considerably higher rates of TP than males in each population tested. Further studies of TP at earlier time-points and in connection to other aspects of craniofacial growth may shed light on these sex and ethnic differences.The amide group has one of the most significant functionalities found in many natural products. Herein, low-nucleophilic amides are used in a Mannich-type reaction to synthesize N-acyl-protected amine derivatives. A highly efficient synthetic method utilizing simple aldehydes, N-substituted anilines, and amides as substrates was established through a one-pot amide pathway activated by hydrogen bonding between the ZnCl2 and amide under solvent-free conditions. This strategy can be broadly applied to medicinal chemistry. More importantly, compared with the previous Lewis acid catalyzed reaction, we proposed a new application of zinc chloride.Nowadays micro-plastic pollution has become one of the most serious global environmental problems. A potential strategy in managing micro-plastic waste is enzyme-catalyzed degradation. MGS0156 is a hydrolase screened from environmental metagenomes, which can efficiently degrade commercial plastics such as polycaprolactone, polylactide, etc. Here a combined molecular dynamics, molecular mechanics Poisson-Boltzmann surface area, and quantum mechanics/molecular mechanism method was used to reveal the enzymatic depolymerization mechanism. By systematically analyzing the binding processes of nine oligomers (from a monomer to tetramer), we found that longer oligomers have relatively stronger binding energy. The degradation process involves two concerted elementary steps triad-assisted nucleophilic attack and C-O bond cleavage. C-O bond cleavage is the rate determining step with an average barrier of 15.7 kcal mol-1, which is consistent with the experimentally determined kcat (1101 s-1, corresponds to 13.3 kcal mol-1). The electrostatic influence analysis of twenty amino acids highlights His231 and Asp237 as potential mutation targets for designing more efficient MGS0156 mutants.Nuclear Quadrupole Resonance (NQR) provides spectra carrying information as to the electric-field gradient around nuclei with a spin quantum number I > 1/2 and offers helpful clues toward characterizing the electronic structure of materials of chemical interest. A major challenge in NQR is finding hitherto unknown resonance frequencies, which can scatter over a wide range, requiring time consuming repetitive measurements with stepwise frequency increments. Here, we report on an efficient, two-step NQR protocol by bringing rapid-scan and frequency-comb together. In the first step, wideband excitation and simultaneous signal acquisition, both realized by a non-adiabatic, frequency-swept hyperbolic secant (HS) pulse with comb modulation, offers a clue for the existence/absence of the resonance within the frequency region under investigation. When and only when the sign of the resonance has been detected, the second step is implemented to compensate the limited detection bandwidth of the first and to unambiguously determine the NQR frequency.

02/11/2025

Democrats Hold ANOTHER Rally Calling For Americans To Violently Resist Trump Admin & Musk’s DOGE Audits https://www.infowars.com/posts/democrats-hold-another-rally-calling-for-americans-to-violently-resist-trump-admin-musks-doge-audits

Videos

12/05/2024

Today on “Truth in Media”, UnitedHealthcare CEO Brian Thompson gunned down by masked assassin in New York City!

Was it personal revenge, or something more sinister? Either way, Americans are scratching their heads...

Meanwhile, Biden is reportedly considering "preemptive pardons" for Anthony Fauci, Liz Cheney, and Adam Schiff. What are they so worried about?

If Trump doesn’t have a legitimate case against Fauci, Cheney, or Schiff, why pardon them? Have they committed any crimes? Perhaps they doth protest too much.

Former CIA Agent John Kiriakou joins Ben Swann to discuss whether Biden is engaging in an unprecedented overreach of his pardon powers...

11/04/2024

Today on “Truth in Media”, Ben Swann looks at where the country stands on election eve.

Noncitizen ballots are challenged in Iowa as election records for 1.2 million voters are handed over to election integrity activists in Arizona.

Kamala Harris appears on SNL as the Trump campaign calls foul play and demands equal air time.

Elon Musk floats working with libertarian Ron Paul to slash government departments in the event of a Trump victory.

And Pennsylvania is neck-and-neck as Americans prepare to get out the vote on Election Day!

10/17/2024

Today on “Truth in Media”, Kamala Harris sets fire to her campaign with a disastrous interview on Fox News with Bret Baier.

Almost 80% of Americans are dissatisfied with the direction of the country. Did Harris not know this and why hasn’t she done anything about it?

TJ Roberts, candidate for Kentucky’s House of Representatives joins Ben Swann to figure out just how much longer Kamala Harris can continue to bomb and still put up competition to former President Donald Trump.

Meanwhile, Kalshi gives Trump a 56% likelihood of winning the presidency, his highest odds yet.

And another $400+ million to Ukraine has all of social media hammering Secretary of State Antony Blinken as a traitor to the American people.

Videos

12/05/2024

Today on “Truth in Media”, UnitedHealthcare CEO Brian Thompson gunned down by masked assassin in New York City!

Was it personal revenge, or something more sinister? Either way, Americans are scratching their heads...

Meanwhile, Biden is reportedly considering "preemptive pardons" for Anthony Fauci, Liz Cheney, and Adam Schiff. What are they so worried about?

If Trump doesn’t have a legitimate case against Fauci, Cheney, or Schiff, why pardon them? Have they committed any crimes? Perhaps they doth protest too much.

Former CIA Agent John Kiriakou joins Ben Swann to discuss whether Biden is engaging in an unprecedented overreach of his pardon powers...

11/04/2024

Today on “Truth in Media”, Ben Swann looks at where the country stands on election eve.

Noncitizen ballots are challenged in Iowa as election records for 1.2 million voters are handed over to election integrity activists in Arizona.

Kamala Harris appears on SNL as the Trump campaign calls foul play and demands equal air time.

Elon Musk floats working with libertarian Ron Paul to slash government departments in the event of a Trump victory.

And Pennsylvania is neck-and-neck as Americans prepare to get out the vote on Election Day!

10/17/2024

Today on “Truth in Media”, Kamala Harris sets fire to her campaign with a disastrous interview on Fox News with Bret Baier.

Almost 80% of Americans are dissatisfied with the direction of the country. Did Harris not know this and why hasn’t she done anything about it?

TJ Roberts, candidate for Kentucky’s House of Representatives joins Ben Swann to figure out just how much longer Kamala Harris can continue to bomb and still put up competition to former President Donald Trump.

Meanwhile, Kalshi gives Trump a 56% likelihood of winning the presidency, his highest odds yet.

And another $400+ million to Ukraine has all of social media hammering Secretary of State Antony Blinken as a traitor to the American people.

“The level of fluoride in the water for 200 million Americans was not at 1/10th of what they know to be a hazardous level.” — Mary Holland, CHD CEO

In other words, many US municipalities have been in violation of the 2016 Toxic Substances Control Act — and a federal judge has agreed.

Here’s the case that Moms Against Fluoridation, Food & Water Watch, and Michael P. Connett, Esq. have been working on for the last seven years.

Full episode: https://x.com/i/broadcasts/1zqKVYzBznwxB

Taxes are notoriously complicated for many Americans, with some tax returns extending over 100 pages. When a whistleblower comes forward with evidence of waste, fraud, abuse, or illegal activities, their concerns are often overlooked. This was the experience of Attorney Thomas Willcox, who faced dismissal after exposing federal and state tax fraud involving Wall Street banks and investment firms. Join us as Mr. Willcox takes us through the labyrinth of blowing the whistle on America’s tax system, with John Kiriakou.

Posts

02/13/2025


In order to better accelerate the transition from traditional trade to cross-border e-commerce, a cross-border e-commerce transportation route optimization model was designed in the context of the prevention and control of new crown pneumonia. Against the background of the new coronavirus pneumonia, through the analysis and research of the current situation of domestic and foreign e-commerce logistics, optimize the cross-border e-commerce logistics distribution model, establish an environmental model, and use efficient search algorithms to search for walking paths that meet environmental requirements. Based on the Dijkstra algorithm model of demand, and based on the linear relationship between demand and delivery distance, an optimal route selection model is established to select the optimal route with the shortest total travel distance. The simulation results show that the cross-border e-commerce transportation time of this model is within 13 h, which is shorter than that of the traditional model. The search efficiency of the optimal route for cross-border e-commerce transportation is higher, and the time for cross-border e-commerce transportation is shorter.Some individuals experience the feeling that they have become a person they had not anticipated. The life path they had expected to take is not consonant with the one they are taking in reality. This perception of "off-course" in identity and self-direction is referred to as derailment. Although previous studies have postulated and demonstrated that derailment causes a low level of well-being, no studies have examined its existence and effect across cultures. We hypothesized that East Asians (Japanese) are less vulnerable to feeling derailed than North Americans (Canadians/Americans), and that those Japanese who feel derailed do not necessarily experience long-term damage to their well-being. Two correlational studies and one longitudinal study with a one-year interval supported these hypotheses and also demonstrated metric invariance of the Derailment Scale between countries. We discuss that these findings may be explained by East Asian's dialectical thinking, in which the perception of one's life direction is flexible.
The online version contains supplementary material available at (10.1007/s10902-021-00375-4).
The online version contains supplementary material available at (10.1007/s10902-021-00375-4).Intramolecular interactions within a protein are key in maintaining protein tertiary structure and understanding how proteins function. Ion mobility-mass spectrometry (IM-MS) has become a widely used approach in structural biology since it provides rapid measurements of collision cross sections (CCS), which inform on the gas-phase conformation of the biomolecule under study. Gas-phase ion/ion reactions target amino acid residues with specific chemical properties and the modified sites can be identified by MS. In this study, electrostatically reactive, gas-phase ion/ion chemistry and IM-MS are combined to characterize the structural changes between ubiquitin electrosprayed from aqueous and denaturing conditions. The electrostatic attachment of sulfo-NHS acetate to ubiquitin via ion/ion reactions and fragmentation by electron-capture dissociation (ECD) provide the identification of the most accessible protonated sites within ubiquitin as the sulfonate group forms an electrostatic complex with accessible protonated side chains. The protonated sites identified by ECD from the different solution conditions are distinct and, in some cases, reflect the disruption of interactions such as salt bridges that maintain the native protein structure. This agrees with previously published literature demonstrating that a high methanol concentration at low pH causes the structure of ubiquitin to change from a native (N) state to a more elongated A state. Results using gas-phase, electrostatic cross-linking reagents also point to similar structural changes and further confirm the role of methanol and acid in favoring a more unfolded conformation. https://www.selleckchem.com/products/napabucasin.html Since cross-linking reagents have a distance constraint for the two reactive sites, the data is valuable in guiding computational structures generated by molecular dynamics. The research presented here describes a promising strategy that can detect subtle changes in the local environment of targeted amino acid residues to inform on changes in the overall protein structure.Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used over-the-counter drugs and their uncontrolled disposal is a significant environmental concern. Although their fluorescent sensing is a desirable method of detection for its sensitivity and simplicity, the structural similarity of the drugs makes the design of selective sensors highly challenging. A thiourea-based fluorescent functional monomer was identified in this work to enable highly efficient synthesis of molecularly imprinted nanoparticle (MINP) sensors for NSAIDs such as Indomethacin or Tolmetin. Micromolar binding affinities were obtained in aqueous solution, with binding selectivities comparable to those reported for polyclonal antibodies. The detection limit was ~50 ng/mL in aqueous solution, and common carboxylic acids such as acetic acid, benzoic acid, and citric acid showed negligible interference.Most older adults will eventually stop driving, but few engage in planning for driving retirement. This study assessed whether driving stress, enjoyment, confidence, concerning driving events, and assessment of driving alternatives influence planning. Demographic factors were also included. Data were collected via a mailed transportation survey, with a final sample of 551 older adults who currently drive. Linear regression analyses revealed that more driving retirement planning was associated with greater driving stress, less driving confidence, and a more positive view of driving alternatives. Driving enjoyment and recent concerning driving events were not significantly related. Among the control variables, race and income were significantly related to planning, suggesting that lower income and identifying as Black race were associated with more planning. Gender only approached significance, suggesting that females may plan more than males. Overall, these findings suggest that more driving retirement planning is warranted.

02/13/2025


The purpose of this paper is to analyze the morphological variation of human populations that inhabited the southern Andes (Mendoza city, Argentina) during 16th to 19th centuries. That period represents an encounter of several distinctive populations inhabiting the same area Europeans, descendants from Europeans (criollos), Africans, and Native Americans. In this paper, we study the shape changes of the cranial base, cranial vault, facial skeleton, and mandible to evaluate if the craniofacial variation differs in relation to the colonial periods and burial areas. For this, we analyzed 44 skulls from four colonial temples of the Foundational Area of Mendoza, and 36 prehistoric ones as a comparative sample. A total of 84 3D anatomical landmarks were registered with a Microscribe G2X. First, we explored the morphological changes by chronological period through a Principal Component Analysis, and then we calculated Mahalanobis distances among the individuals from different chronological periods. Second, we evaluated the morphological variation of the colonial subsample according to chronological period, archaeological site, and burial area. https://www.selleckchem.com/products/az-3146.html For this, we conducted a Principal Component Analysis and a MANOVA. We represent the morphological changes by Wireframes that show the main variation along PC1 and PC2. The results obtained showed morphological differences in the cranial base and facial skeleton of the individuals from different chronological periods, while the cranial base and mandible vary when comparing individuals from different burial areas. We conclude that the colonial society was highly diverse in terms of biological and cultural variation, and that there were differential dietary patterns among them.Discrete, small, roundish lesions of localized porous bone can be occasionally seen in the craniofacial skeleton. Such lesions are rarely mentioned and only occur as an incidental discovery being assigned to plenty of diagnoses. As an example, such multiple small lesions of the facial skeleton in a well-preserved skeleton of a 40-60 year old male of the Hunno-Sarmatian Period from Kazakhstan, are discussed. Some of the lesions were examined by digital microscopy, plain radiography, and plain and polarizing microscopy. Considering possible differential diagnoses of vascular, traumatic, inflammatory/reactive, metabolic, and neoplastic entities, as well as developmental conditions, its microscopic characteristics point to a fibro-osseous process. This paper intends to open a discussion on the diagnosis of such lesions, which have been relatively neglected in previous research.Objectives Torus Palatinus (TP) is a bony projection located on the oral surface of the hard palate. The trait is typically benign, has an unknown etiology, and varies widely in phenotypic expression. Prior studies suggest differences in TP prevalence by sex and ancestry, but the reported rates vary, even within a single ancestral group. We assessed the prevalence of TP and its association with palatal shape in a large multi-ethnic cohort of normal individuals. Methodology 1102 adults were included (625 with European ancestry, 377 with West African anscestry, and 100 with East Asian ancestry). 3D digital dental casts were obtained and rated. TP frequencies were compared between sexes and/or ethnicities using Chi-squared tests. Dental cast models were then landmarked, and canonical variates analysis was performed to test for shape differences between those with and without TP. Results Females had a significantly higher rate of TP than males across all three ancestral groups (p≤0.004). In males, no significant differences were found among ethnicities. Ancestral differences in TP frequency were driven by females, with East Asians having the highest rate (34.69%), followed by Europeans (24.88%) and West Africans (15.22%). Shape differences were found only in Asians and Africans, indicated a shorter and wider palate in presence of TP. Conclusions Ethnic differences in TP frequency were present only in females. Further, females have considerably higher rates of TP than males in each population tested. Further studies of TP at earlier time-points and in connection to other aspects of craniofacial growth may shed light on these sex and ethnic differences.The amide group has one of the most significant functionalities found in many natural products. Herein, low-nucleophilic amides are used in a Mannich-type reaction to synthesize N-acyl-protected amine derivatives. A highly efficient synthetic method utilizing simple aldehydes, N-substituted anilines, and amides as substrates was established through a one-pot amide pathway activated by hydrogen bonding between the ZnCl2 and amide under solvent-free conditions. This strategy can be broadly applied to medicinal chemistry. More importantly, compared with the previous Lewis acid catalyzed reaction, we proposed a new application of zinc chloride.Nowadays micro-plastic pollution has become one of the most serious global environmental problems. A potential strategy in managing micro-plastic waste is enzyme-catalyzed degradation. MGS0156 is a hydrolase screened from environmental metagenomes, which can efficiently degrade commercial plastics such as polycaprolactone, polylactide, etc. Here a combined molecular dynamics, molecular mechanics Poisson-Boltzmann surface area, and quantum mechanics/molecular mechanism method was used to reveal the enzymatic depolymerization mechanism. By systematically analyzing the binding processes of nine oligomers (from a monomer to tetramer), we found that longer oligomers have relatively stronger binding energy. The degradation process involves two concerted elementary steps triad-assisted nucleophilic attack and C-O bond cleavage. C-O bond cleavage is the rate determining step with an average barrier of 15.7 kcal mol-1, which is consistent with the experimentally determined kcat (1101 s-1, corresponds to 13.3 kcal mol-1). The electrostatic influence analysis of twenty amino acids highlights His231 and Asp237 as potential mutation targets for designing more efficient MGS0156 mutants.Nuclear Quadrupole Resonance (NQR) provides spectra carrying information as to the electric-field gradient around nuclei with a spin quantum number I > 1/2 and offers helpful clues toward characterizing the electronic structure of materials of chemical interest. A major challenge in NQR is finding hitherto unknown resonance frequencies, which can scatter over a wide range, requiring time consuming repetitive measurements with stepwise frequency increments. Here, we report on an efficient, two-step NQR protocol by bringing rapid-scan and frequency-comb together. In the first step, wideband excitation and simultaneous signal acquisition, both realized by a non-adiabatic, frequency-swept hyperbolic secant (HS) pulse with comb modulation, offers a clue for the existence/absence of the resonance within the frequency region under investigation. When and only when the sign of the resonance has been detected, the second step is implemented to compensate the limited detection bandwidth of the first and to unambiguously determine the NQR frequency.

02/11/2025

Democrats Hold ANOTHER Rally Calling For Americans To Violently Resist Trump Admin & Musk’s DOGE Audits https://www.infowars.com/posts/democrats-hold-another-rally-calling-for-americans-to-violently-resist-trump-admin-musks-doge-audits

Americans see Trump getting the job done, pollster says

https://www.brighteon.com/8f972dd5-ec31-4065-8650-286fed968b10

Americans see Trump getting the job done, pollster saysSubscribe to Brighteon newsletter to get the latest news and more featured videos:https://support.brighteon.com/Subscribe.html

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02/11/2025


Whites and Hispanics were victims most diagnosed with concussion and DV, but Native Americans and Blacks comprised a much greater proportion of diagnoses compared with the representative state demographics. Although likely underreported, approximately half of the cases were inflicted by intimate partners, which corresponded closely to marital status. Surprisingly, 61% of victims sought medical treatment for non-concussion injuries and then concussion was entered as a primary diagnosis. The demographic and health care facility disparities demand TBI/concussion screening in suspected DV patients, education and training of care providers, and potential redistribution of resources to select health care facilities.Martian lava tube caves resulting from a time when the planet was still volcanically active are proposed to contain deposits of water ice, a feature that may increase microbial habitability. In this study, we taxonomically characterized and directly measured metabolic activity of the microbial communities that inhabit lava tube ice from Lava Beds National Monument, an analogue environment to martian lava tubes. We investigated whether this environment was habitable to microorganisms by determining their taxonomic diversity, metabolic activity, and viability using both culture-dependent and culture-independent techniques. With 16S rRNA gene sequencing, we recovered 27 distinct phyla from both ice and ice-rock interface samples, primarily consisting of Actinobacteria, Proteobacteria, Bacteroidetes, Firmicutes, and Chloroflexi. Radiorespiration and Biolog EcoPlate assays found these microbial communities to be metabolically active at both 5°C and -5°C and able to metabolize diverse sets of heterotrophic carbon substrates at each temperature. Viable cells were predominantly cold adapted and capable of growth at 5°C (1.3 × 104 to 2.9 × 107 cells/mL), and 24 of 38 cultured isolates were capable of growth at -5°C. Furthermore, 14 of these cultured isolates, and 16 of the 20 most numerous amplicon sequences we recovered were most closely related to isolates and sequences obtained from other cryophilic environments. Given these results, lava tube ice appears to be a habitable environment, and considering the protections martian lava tubes offer to microbial communities from harsh surface conditions, similar martian caves containing ice may be capable of supporting extant, active microbial communities.Antimicrobial resistance (AMR) is a recognized global public health concern. Although the link between antimicrobial usage in food animals and AMR in humans is established, the detailed interactions are unclear. Antimicrobial stewardship (AMS) in livestock was first implemented in Europe with Sweden as the pioneer in 1986. Despite this head start, AMR is still an ongoing challenge for Europe. The European Union (EU) is an established agriculture producer, the second largest pork producer globally, and one of the largest markets for organic food. China is the global leader in both production and consumption of pork. China's rise in prosperity has led to an increase in its pork demand. Chinese producers commonly use antimicrobials during production for disease treatment and prevention to meet this increased demand. China's rising prosperity together with recent publicized food safety scandals, disease outbreaks in domestic livestock products, and increased AMR awareness have resulted in an increased willingness to pay and demand for organic food by Chinese consumers. Responding to the growing concerns of AMR by consumers and the World Health Organization (WHO), the Chinese government introduced a national pilot program in 2016 to reduce unnecessary antimicrobial use. Compared with China, the EU is a different entity as it is a political union comprising diverse countries and although it may have more experience in AMS, both entities face similar issues with AMR and increasing demand for organic food. Increased interest in organic food has arisen due to concerns about AMR, food safety, outbreaks of bacterial food contamination, and animal welfare. This article aims to compare the different AMS strategies employed by each entity, China and the EU, and how the increased demand for organic produce globally also influences the effort to reduce antimicrobial use in these entities' pork industries.As part of a broader project to create a comprehensive self-report measure for the Hierarchical Taxonomy of Psychopathology consortium, we developed preliminary scales to assess internalizing symptoms. The item pool was created in four steps (a) clarifying the range of content to be assessed, (b) identifying target constructs to guide item writing, (c) developing formal definitions for each construct, and (d) writing multiple items for each construct. This yielded 430 items assessing 57 target constructs. Responses from a heterogeneous scale development sample (N = 1,870) were subjected to item-level factor analyses based on polychoric correlations. This resulted in 39 scales representing a total of 213 items. The psychometric properties of these scales replicated well across the development sample and an independent validation sample (N = 496 adults). Internal consistency analyses established that most scales assess relatively narrow forms of psychopathology. Structural analyses demonstrated the presence of a strong general factor. Additional analyses of the 35 nonsexual dysfunction scales revealed a replicable four-factor structure with dimensions we labeled Distress, Fear, Body Dysmorphia, and Mania. A final set of analyses established that the internalizing scales varied widely-and consistently-in the strength of their associations with neuroticism and extraversion.Purpose To evaluate the efficacy of topical ketorolac tromethamine 0.5% given pre-emptively a day before, for alleviating pain in patients undergoing panretinal photocoagulation (PRP) treatment. https://www.selleckchem.com/products/FK-506-(Tacrolimus).html Methods A controlled single-blinded study was conducted on 33 patients with diabetic retinopathy (DR; severe nonproliferative DR, proliferative DR, or advanced diabetic eye disease) who required PRP treatment in both eyes simultaneously. Each eye of the patients was randomly assigned for ketorolac tromethamine 0.5% eyedrop or placebo. Both eyedrop bottles were randomly labeled. Eyedrops were self-administered by the patients, 4 times a day before the procedure (at 6 am, 12 noon, 6 pm, and 12 midnight) and every 15 min for 1 h (4 times) before the laser. Each patient was subjected to PRP using a Visulas 532s Zeiss device set to spot size 200 μm, time 0.10 s, and ∼600 burns in each eye. The pain score was evaluated immediately after treatment in each eye independently with Scott's visual analog scale (VAS) and the McGill Pain Questionnaire (MPQ).