03 (p less then 0.05) which indicates that there is a relationship between food consumption and income. Conclusion There is a relationship between staple food consumption and household income in pregnant and lactating women.Objective The Integrated Referral System (SISRUTE) is a health service referral system that regulates the delegation of tasks and responsibilities, which are processed in an integrated manner. https://www.selleckchem.com/products/skf38393-hcl.html The study aims to analyze the system used, system quality, information quality, and service quality toward physician satisfaction in using the Integrated Referral System (SISRUTE). Methods The sample in this study was physicians who served in the ED, as many as 33 respondents. Using a mixed method with cross-sectional design. Results The results showed that there was no relationship (p=0.126>0.05) between humans in using the system with physician satisfaction in using SISRUTE, there was no relationship (p=0.393>0.05) between system quality and physician satisfaction in using SISRUTE, there is a relationship (p=0.002 less then 0.05) information quality with physician satisfaction in using SISRUTE, and there is a relationship (p=0.001 less then 0.05) service quality with physician using SISRUTE.Objective Dengue hemorrhagic fever (DHF) is an infectious disease caused by the dengue virus which results in acute fever. Methods Design of this study was a survey method with short duration Quasi-Experimental. The sample in this study was 240 houses. Results Results showed that intervention by giving abathion in the village of Rhino I natural gas, Salo Palai and Muara Badak Ilir villages was effective in eliminating larvae with value Z=4.750, p=0.000. Conclusion Aedes aegypti larvae are suggested to need cross-sectoral cooperation, providing data on the presence of Aedes aegypti larvae and increasing efforts to eradicate mosquito nests.Objective This study aimed to analyze the determinant of parenting self-efficacy at parents of children aged 0-12 months at the talise health centre work area Palu city. Methods The research was conducted in talise health centre, the method used is cross sectional. The total sample of 149 samples that met the study criteria. Data was collected by questionnaire interviews. Analysis of data using statistical test Chi-square and logistic regression. Results There is influence of knowledge, social support, experience, temperament and fatigue of parenting self-efficacy p0.05. Conclusion For holders of the expected policy need to be holding seminar parenting enrichment, training or discussions held by health centre collaboration with volunteers to further improve parental knowledge related to parenting.Objective This study aims to determine the risk factors for the incidence of LBW. Methods The research uses observational analytic with a case-control study design with a sample of 126 people, the data were analyzed using chi-square and multiple logistic regression. Results There were 3 variables which were risk factors for the incidence of LBW, exposure to cigarette smoke with OR=3.441, nutritional status OR=3.224, and utilization of ANC OR=3.185, with a significance level of each p less then 0.05). Conclusion Pregnant women are advised to routinely check their pregnancy, with a minimum of 4 examinations during pregnancy because by carrying out ANC all factors can be prevented, abnormalities that might arise quickly are known and immediately overcome before adversely affecting pregnancy.Objective This study aims to determine the determinant factors associated with the amount of Specific Rubella IgG levels in women of childbearing age. Methods The study design used observational analytic with cross-sectional, while sample was women of childbearing age who were in Maelang Health Center, as well as fulfilling the specified inclusion criteria 125 samples. Results There was no significant relationship between age (p=0.097), type of work (p=0.302), education (p=0.160), income (p=0.099) and parity (p=0.314) with immunological status rubella, and significant is history of miscarriage (p=0.027). Multivariate analysis showed history of miscarriage was dominant factor in immunological status of rubella (p=0.027; OR=5.469). Conclusion It is expected that health workers in study area increase counseling about the danger of rubella virus either at posyandu or subdistrict level musrembang activities and government is expected to support and provide latest innovations.Background Adenocarcinoma is the most common of lung Cancer. The treatment for early stage of lung Adenocarcinoma (I, II) is surgery. Targeted therapy is given to lung Adenocarcinoma patients with EGFR-TKI mutations. Chemotherapy is given to lung Adenocarcinoma patients without EGFR-TKI mutations. Objective To compare one-year survival of lung Adenocarcinoma patients treated with chemotherapy or targeted therapy. Methods This was a prospective study. The subjects were 100 patients with lung Adenocarcinoma. Results 1-year Survival of lung Adenocarcinoma patient for one year was 18%. 1-year survival in patients with targeted therapy was higher than chemotherapy, which was 24% vs 9% (p0.05). 1-Year survival in patients with Erlotinib drug was 45% highest survival rate compared to chemotherapy drugs and other targeted therapy (p less then 0.05). Patients receiving Erlotinib (45%) has the highest survival compared to all types of therapy. Conclusion Lung Adenocarcinoma patients receiving Erlotinib significantly had the highest survival rate compared to all other targeted therapy drugs and all types of chemotherapy drugs.Objective This study aimed to determine the effect of cork extract on albumin levels and protein intake in hypoalbuminemic patients at Wahidin Sudirohusodo Hospital. Methods This study was a quasi-experimental study with a randomized controlled trial (RCT) design, then divided into 2 intervention and control groups each consisting of 17 people. Results Data analysis showed that albumin level of intervention group 2.95±0.28 increased to 3.17±0.39 (p=0.011). In control group 2.93±0.27 decreased to 2.88±0.49 (p=0.527). For protein intake in intervention group 56.27±25.95 to 91.10±26.17 (p=0.002). In control group 42.26±13.78 to 54.66±17.62 (p=0.032). And for hemoglobin intervention group from 10.83±2.46 increased 11.30±1.65 but statistically not significant (p=0.345), while in control group 10.78±1.28 to 10.86±1.44 (p=0.765). Conclusion There was an effect of giving cork fish extract (Pujimin Plus) to albumin levels and protein intake in hypoalbuminemic patients.

To investigate the risk factors of citrate accumulation in patients with liver failure treated with regional citrate anticoagulated continuous renal replacement therapy (RCA-CRRT).

The clinical data of liver failure patients with RCA-CRRT admitted to department of intensive care unit (ICU) of Nantong Third People's Hospital from January 2017 to June 2020 were retrospectively analyzed. The selected patients were divided into citrate accumulation group and control group according to whether there was citrate accumulation (serum total calcium/free calcium ratio ≥ 2.4) during CRRT. The age, acute physiology and chronic health evaluation II (APACHE II), mean arterial pressure (MAP), norepinephrine (NE) dose, blood lactic acid (Lac) concentration, liver function status, citrate dose, filter time and prognosis of the patients were compared between the two groups. Unconditional Logistic regression was used to analyze the risk factors for citrate accumulation.

Among 48 patients with RCA-CRRT and liver failure, 2lation.
In patients with tissue hypoperfusion and severe liver function damage, citrate anticoagulation should be avoided or the dosage of citric acid should be reduced, in order to avoid citrate accumulation.
To investigate the value of quantitative electroencephalography (qEEG) in the evaluation of thrombolytic efficacy in acute cerebral infarction.

A prospective cohort study was conducted. Ninety-four patients with acute cerebral infarction who received intravenous thrombolysis admitted to the department of emergency of Qinhuangdao First Hospital from October 2019 to September 2020 were enrolled. The relative energy values of δ, θ, α and β waves in qEEG before and 2 hours, 24 hours and 7 days after intravenous recombinant tissue plasminogen activator (rt-PA) thrombolysis were dynamically monitored, and the power ratio index [DTABR, DTABR = (δ+θ)/(α+β)] was calculated. The National Institutes of Health stroke scale (NIHSS) score was also recorded. The reduction of NIHSS score ≥ 3 or the disappearance of neurological symptoms were regarded as effective thrombolytic therapy. The changes of DTABR before and after thrombolysis in patients with effective and ineffective thrombolysis were analyzed, and the correlat= 0.691, P < 0.01).

The quantitative index of qEEG, DTABR, can accurately and quickly monitor the process of thrombolysis in acute cerebral infarction, and can effectively evaluate the effect of thrombolysis in patients.
The quantitative index of qEEG, DTABR, can accurately and quickly monitor the process of thrombolysis in acute cerebral infarction, and can effectively evaluate the effect of thrombolysis in patients.
To investigate the protective effect and potential mechanism of cordycepin on renal proximal tubular cells injury induced by lipopolysaccharide (LPS).

Renal proximal tubular cells NRK-52E were incubated on a cell culture plated at a density of 1×10
/mL for experiment, then divided into control group (Ctrl group), LPS group (cells were stimulated with 1 mg/L LPS), 10 μmol/L or 20 μmol/L cordycep in intervention groups (LPS+C 10 group and LPS+C 20 group). Cell viability was measured using cell counting kit-8 (CCK-8) reagent. The level of intracellular reactive oxygen species (ROS) was detected by 2',7'-dichlorofluorescin diacetate (DCFH-DA) staining. https://www.selleckchem.com/products/ly3200882.html The protein expressions of inflammatory factors intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), interleukin-1β (IL-1β), and nuclear factor-κB (NF-κB) were detected by Western blotting.

Compared with the Ctrl group, LPS significantly inhibited NRK-52E cell viability, increased intracellular ROS, and up-regulated thDH 1.561±0.074 vs. 2.364±0.097, VCAM-1/GAPDH 1.920±0.098 vs. 2.866±0.135, IL-1β/GAPDH 1.563±0.179 vs. 2.358±0.107, NF-κB p-p65/GAPDH 1.596±0.148 vs. 2.559±0.166, all P < 0.05).

Cordycepin could significantly increase the survival rate of NRK-52E cells, reduce intracellular ROS level, and inhibit inflammation, and the anti-inflammation effect can be related with NF-κB pathway.
Cordycepin could significantly increase the survival rate of NRK-52E cells, reduce intracellular ROS level, and inhibit inflammation, and the anti-inflammation effect can be related with NF-κB pathway.
To explore the damage of the intestinal mucosal barrier of septic rats by the activation of NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasomes and the role of Ulinastatin (UTI) on the expression of intestinal nuclear factor-κB (NF-κB)/NLRP3 inflammasome signaling pathway in septic rats.

According to the random number table method, 64 male Wistar rats were divided into sham operation group (Sham group), cecal ligation and puncture (CLP) group, UTI treatment group (100 kU/kg UTI was intraperitoneally injected 1, 6, 12 and 18 hours after CLP), and UTI pretreatment group (100 kU/kg UTI was given 1 hour before CLP), with 16 rats in each group. The survival of rats was observed after 24 hours, and the blood was collected from abdominal aorta at 24 hours after modeling, then rats were killed and their ileum tissues were taken. Hematoxylin-eosin (HE) staining was used to observe histopathological changes and Chiu score. The levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) amucosa may be related to inhibiting the activation of NLRP3 inflammasomes in the intestinal mucosa, but UTI pretreatment has no obvious advantage compared with UTI treatment.
Intestinal barrier dysfunction in sepsis may be related to the activation of NLRP3 inflammasomes in the intestinal mucosa. The protective effect of UTI in the intestinal mucosa may be related to inhibiting the activation of NLRP3 inflammasomes in the intestinal mucosa, but UTI pretreatment has no obvious advantage compared with UTI treatment.
To analyze the risk factors and clinical characteristics of liver injury in patients with sepsis and to provide a reference for early recognition, early diagnosis, early intervention, and improve the survival rate of patients.

The clinical data of sepsis patients admitted to the department of general intensive care unit (ICU) of the Second Affiliated Hospital of Zhejiang University School of Medicine from July 2014 to October 2020 were retrospectively analyzed. According to the occurrence of acute liver injury, patients with sepsis were divided into the liver injury group and the non-liver injury group, and the differences of demographic data, history, history of primary diseases, laboratory indicators on the first time of admission, treatments, the severity of the disease and other indicators were compared and analyzed. Logistic regression was used to analyze the risk factors for sepsis-related liver injury.

A total of 527 patients with sepsis were enrolled, and 129 patients with acute liver injury, accounting for 24.

04, ES = 0.52) to very large (forwards PlayerLoad, p less then 0.001. ES = 2.25; PlayerLoad·min, p less then 0.001, ES = 2.66; EEs, p less then 0.001, ES = 2.03; Medium SL, p less then 0.001, ES = 2.31; SL·min, p less then 0.001, ES = 2.67), respectively. The differences in external load measures of intensity demonstrate the need to alter training programs of subelite ice athletes to ensure they can meet the demands of elite ice hockey. As athletes advance along the development pathway, considerable focus of their off-ice training should be to improve qualities that enhance their ability to perform high-intensity on-ice movements.Molina Correa, JC, Padoin, S, Varoni, PR, Demarchi, MC, Flores, LJ, Nampo, FK, and de Paula Ramos, S. Ergogenic effects of photobiomodulation on performance in the 30-second Wingate test A randomized, double-blind, placebo-controlled, crossover study. J Strength Cond Res XX(X) 000-000, 2020-The purpose of this study was to evaluate the ergogenic effects of red light (630 nm) photobiomodulation on anaerobic capacity in the Wingate test. Sixteen healthy and physically active male volunteers (21.71 ± 2.49 years of age, body mass index between 18.5 and 24.9 kg/m) participated in this randomized, double-blind, placebo-controlled, crossover study. The subjects performed 3 Wingate test sessions, with a 48-hour interval between tests. In the first session (baseline session, BS), a Wingate test was performed to evaluate the initial performance. Subjects were paired by performance in the BS and allocated through a draw to receive either the phototherapy (630 nm, 4.6 J/cm, 6 J per point, 16 points, light-emitting diode [LED] session) or placebo intervention (PLA session) in the second test session. In the third test session, a crossover intervention was performed. The repeated-measures analysis of variance test, followed by Bonferroni post hoc test or Friedman test with Dunn's post hoc test (p less then 0.05) and Cohen's d statistic were used for comparisons. The LED session with phototherapy promoted an increase in performance in peak power (p less then 0.05), relative power (p less then 0.05), RPMpeak (p less then 0.05), and peak velocity (p less then 0.05), as well as total displacement (p less then 0.01) compared with PLA. The mean power (p less then 0.05), relative power (p less then 0.05), RPMmean (p less then 0.01), and mean velocity (p less then 0.01) were higher in the LED session than those of BS. We concluded that phototherapy improves performance in Wingate anaerobic exercise, possibly due to large effects on the anaerobic alactic metabolism.Mitchell, UH, Owen, PJ, Rantalainen, T, and Belavý, DL. Increased joint mobility is associated with impaired transversus abdominis contraction. J Strength Cond Res XX(X) 000-000, 2020-Increased joint mobility is a risk factor for joint injury, but muscle function may be able to compensate for it. https://www.selleckchem.com/products/byl719.html Current evidence suggests reduced force production capacity in people with hypermobility. However, little is known about the lumbar spine. The purpose of this cross-sectional study was to assess whether there was a link between joint mobility and transverse abdominis and multifidus muscles contraction, muscles ascribed a core-stability role. Using a modified quantitative version of the Beighton scale (BOM score), we measured joint mobility of 30 middle-aged individuals without low back pain. These scores were correlated with magnetic resonance imaging-derived measures of transverse abdominis and multifidus muscle contraction during a spinal loading maneuver. The level of significance was set for p ≤ 0.05. The results showed greater joint mobility (a higher BOM score) correlated (r = 0.468; p = 0.009) with reduced transversus abdominis (TrA) shortening during contraction (i.e., less muscle shortening in people with greater joint mobility). The trunk subdomain score exhibited a correlation of 0.354 with TrA length change, but this did not reach statistical significance (p = 0.055). The subdomains of the BOM score did not correlate significantly with each other (p ≥ 0.097). No association was seen between multifidus contraction and joint mobility. The results suggest that greater general joint mobility is associated with impaired contraction of the TrA muscle. This should be considered when coaching athletes or treating patients with (functional) spinal instability. The quantitative approach we developed to measure joint mobility could be used in the future studies of global flexibility.Tan, J, Shi, X, Witchalls, J, Waddington, G, Lun Fu, AC, Wu, S, Tirosh, O, Wu, X, and Han, J. Effects of pre-exercise acute vibration training on symptoms of exercise-induced muscle damage a systematic review and meta-analysis. J Strength Cond Res XX(X) 000-000, 2020-Exercise-induced muscle damage (EIMD) normally occurs after unaccustomed high-intensity eccentric exercises. Symptoms of EIMD include delayed-onset muscle soreness (DOMS), tenderness, stiffness, swelling, reduced strength, and increased creatine kinase (CK) levels in the blood. Vibration training (VT) may be useful as a pre-exercise intervention in attenuating EIMD on the basis of tonic vibration reflex (TVR) through a more efficient distribution of contractile stress over muscle fibers. The objective of this meta-analysis is to examine the effects of acute VT on symptoms of EIMD when performed as the pre-exercise intervention. Randomized controlled trials (RCTs) published in the 8 databases of Cochrane Library, PubMed, Embase, Web of Science, EBnce to demonstrate that receiving acute VT before unaccustomed high-intensity eccentric exercises may be effective in attenuating markers of muscle damage and the development of DOMS when compared with a control group. The possible mechanisms of this effect could be attributed to an improved synchronization of muscle fiber caused by TVR, which could result in even distribution of exterior loads and eventually attenuate disruptions of muscle fibers. In addition, increased blood flow may also be helpful to prevent accumulation of metabolic substances and attenuate subsequent symptoms of EIMD. Vibration training may be used as a pre-exercise intervention to alleviate symptoms of EIMD caused by unaccustomed high-intensity eccentric exercise. Because of the limited quantity and quality of included studies, more high-quality studies are required to ascertain the effect of VT on symptoms of EIMD.

l absorption of contaminants.Standard infant formula and specialised infant formula for medical purposes in Denmark (n = 42) were assessed for the levels of 2-MCPDEs, 3-MCPDEs, and GEs. Similar concentrations of GEs were observed in both standard and specialised powder infant formula at around 11.5 µg/kg. For 2-MCPDEs and 3-MCPDEs, significantly higher concentrations were observed in specialised products (18.0 and 49.8 µg/kg, respectively) in comparison with the standard ones (11.8 and 31.0 µg/kg, respectively). The concentration profiles also revealed discrepancies in MCPDEs and GEs concentrations not only between different manufacturers but also in terms of infant formula variety. For instance, the hypoallergenic powder formula showed twice as much MCPDEs as the normal formula variety. Exposure estimation using average contaminant concentrations in each variety suggested no potential risk of 3-MCPDEs and GEs intake for Danish infants via infant formula consumption. However, special attention is required for a few specific products where risks might occur in terms of 3-MCPDEs and/or GEs consumption.Objective In professional sports activities, the search for increased performance is constant. Electrophysical agents, including photobiomodulation (PBM), have been used in the sports context to accelerate postworkout recovery, prevent injuries, and even to improve performance. This study aims to investigate the effects of infrared laser (904 nm) on skeletal muscle gene expression of performance-related proteins of rats submitted to a chronic resistance training protocol. Materials and methods Male Wistar rats (n = 40), weighing ±300 g were divided into four groups sedentary control (CT, n = 10); irradiated control (CTL, n = 10); exercised not irradiated (EX, n = 10); exercised irradiated (EXL, n = 10). To assess the performance, the maximum carrying test was adapted and applied 72 h prior the training and 72 h after the last exercise session. https://www.selleckchem.com/products/OSI-930.html The vertical weight climbing protocol was adapted for resistance training 3 × per week with 48 h interval between each session first week adaptation, second week 25% of body weight (BW), third week 50% BW, fourth week 75% BW, and fifth week 100% BW. Animals were irradiated before exercise on hind paws 50 sec each, with infrared laser 904 nm 5 days per week, during 4 weeks, 9 J per leg in a total of 18 J energy per day. Results The EXL performed more climbing (7.1 ± 0.91) compared to EX (4.4 ± 0.63). PBM promoted increased expression of lactate dehydrogenase enzyme, mammalian target of rapamycin protein, and androgen receptor (p  less then  0.05) but not the myosin heavy chain (p = 0.43). Conclusions PBM therapy increases the expression of performance-related muscle mass gain genes besides improving the resistance training performance.Many researchers have pointed out that coffee contributes significantly to the dietary exposure among the many foods that contain acrylamide. Within the context of this study, the 24 h dietary recall method was employed to obtain the coffee consumption information of 263 individuals with different socio-demographic characteristics, followed by an estimation based on the deterministic model and an analysis of statistical data, in an attempt to estimate acrylamide exposure from coffee. The acrylamide intake of individuals who consume coffee was estimated to be 0.11 ± 0.084 µg/kg bw per day (95th percentile, 0.27 µg/kg bw per day); the exposure of women was estimated to range on an average between 0.12 ± 0.097 µg/kg bw per day while the exposure of men was estimated to range between 0.10 ± 0.065 µg/kg bw per day. A statistically significant difference (p less then .05) was detected in the estimated average values between the parameters of age group, education level and coffee types consumed. Dietary acrylamide exposure was not of concern with respect to neurotoxicity and carcinogenicity. This is the first study carried out to estimate acrylamide exposure of individuals in Turkey from coffee.Background The diagnosis of sleep bruxism (SB) in children is difficult due to the lack of a polysomnographic protocol for this population. Moreover, the gold standard treatment [occlusal splint (OS) therapy] has limitations, as adequate use depends on the child's cooperation. The etiology of SB may include stress factors. Salivary cortisol is a biomarker used as a noninvasive method to evaluate the response to stress. Besides physiological aspects, it is also important to investigate morphological aspects, such as masticatory muscle strength. The aim of the present study was to determine the occurrence of bite marks on the buccal mucosa in children as a complementary sign for the diagnosis of SB and investigate and the effectiveness of photobiomodulation as an alternative treatment for this condition. Methods Seventy-six children 6-12 years of age were divided into four groups G1-with SB and submitted to laser therapy over acupuncture points (λ = 786.94 nm, 20 sec per point, fluency = 33.5 Jcm2, energy = 1 Jof SB. Children with SB responded well to photobiomodulation therapy, as evidenced by the reduction in BF and reports of headache.
The Netherlands Donor Feces Bank provides standardized ready-to-use donor faecal suspensions for faecal microbiota transplantation treatment of patients with recurrent
infection.

The purpose of this study was evaluation of safety, feasibility and outcome of faecal microbiota transplantation facilitated by a national stool bank.

The methods used included observational cohort study of donors and recipients of faecal suspensions; assessment of donor screening and patient selection performed by an expert panel of medical microbiologists, gastroenterologists and infectious disease specialists; and patient outcome evaluated at different timepoints after faecal microbiota transplantation.

Of 871 volunteers who registered as a potential faeces donor, 16 (2%) became active donors. Nine donors stopped or were excluded after a mean donation period of 5.7 months. In 2016-2019, 47 (27%) of 176 requests for faecal microbiota transplantations were deemed not indicated by the expert panel. In total, 129 patients with recurrent
infection were treated with 143 faecal suspensions in 40 different hospitals.

The economic burden was reduced of US$1 056 699 and US$2 328 531 from the provider and societal perspectives, respectively. The cost-effectiveness estimates were mostly sensitive to the discount rate and the cost of outpatient visits at health facilities. The intervention remained dominant with a 100% probability of cost savings within 10 000 simulations of the sensitivity analysis.

Providing inexpensive diarrheal treatment (oral rehydration salts and zinc) in communities is an attractive cost-effective intervention. Evidence from this study should be used to scale up the coverage of this life- and cost-saving intervention.
Providing inexpensive diarrheal treatment (oral rehydration salts and zinc) in communities is an attractive cost-effective intervention. Evidence from this study should be used to scale up the coverage of this life- and cost-saving intervention.Monoacylglycerol lipase (MAGL) is an enzyme belonging to the endocannabinoid system that mainly metabolizes the endocannabinoid 2-arachidonoylglycerol (2-AG). Numerous studies have shown the involvement of this enzyme in various pathological conditions such as pain, cancer progression, Parkinson's and Alzheimer's disease, thus encouraging the development of new MAGL modulators. In this context, we developed new diphenylsulfide-benzoylpiperidine derivatives characterized by a high enzymatic MAGL inhibition activity in the low nanomolar range, a reversible mechanism of action and selectivity. The three most active compounds (15-17) induced an appreciable inhibition of cell viability in a panel of nine cancer cell lines, with IC50 values ranging between 0.32 and 10 μM, thus highlighting their potential as novel anticancer agents.Helicobacter pylori is one of the main causal risk factor in the generation of chronic gastritis, gastroduodenal ulcers and gastric carcinoma. Thus, the eradication of H. pylori infection is an important way for preventing and managing the gastric diseases. Multiple-therapy with several antibacterial agents is used for the eradication of H. pylori infections; however the increase of resistance to H. https://www.selleckchem.com/products/20-hydroxyecdysone.html pylori strains has resulted in unsatisfactory eradication and unsuccessful treatment. Furthermore, the combination therapy with high dosing leads to the disruption of intestinal microbial flora and undesired side effects. Therefore, the search for new therapeutic agents with high selectivity against H. pylori is a field of current interest. In recent years, diverse compounds originating from natural sources or synthetic drug design programs were evaluated and tried to optimize for applying against H. pylori. In this review, we have described various classes of anti-H. pylori compounds, their structure-activity relationship studies, and mechanism of actions, which could be useful for the development of new drugs for the treatment of H. pylori infections.Sepsis, a systemic inflammatory response, caused by pathogenic factors including microorganisms, has high mortality and limited therapeutic approaches. Herein, a new soluble epoxide hydrolase (sEH) inhibitor series comprising a phenyl ring connected to a memantyl moiety via a urea or amide linkage has been designed. A preferential urea pharmacophore that improved the binding properties of the compounds was identified for those series via biochemical assay in vitro and in vivo studies. Molecular docking displayed that 3,5-dimethyl on the adamantyl group in B401 could make van der Waals interactions with residues at a hydrophobic pocket of sEH active site, which might indirectly explain the subnanomolar level activities of memantyl urea derivatives in vitro better than AR-9281. Among them, compound B401 significantly improved the inhibition potency with human and murine sEH IC50 values as 0.4 nM and 0.5 nM, respectively. Although the median survival time of C57BL/6 mice in LPS-induced sepsis model was slightly increased, the survival rate did not reach significant efficacy. Based on safety profile, metabolic stability, pharmacokinetic and in vivo efficacy, B401 demonstrated the proof of potential for this class of memantyl urea-based sEH inhibitors as therapeutic agents in sepsis.A series of diphenylpyrimidine derivatives bearing a hydroxamic acid group was designed and synthesized as noncovalent EGFRT790M/L858R inhibitors to improve the biological activity and selectivity. One of the most promising compound 9d effectively interfered EGFRT790M/L858R binding with ATP and suppressed the proliferation of H1975 cells with IC50 values of 1.097 nM and 0.09777 μM, respectively. Moreover, compound 9d also not only exhibited a high selective index of 43.4 for EGFRT790M/L858R over the wild-type and 10.9 for H1975 cells over A431, but also exhibited low toxicity against the normal HBE cells (IC50 > 20 μΜ). In addition, the action mechanism validated that compound 9d effectively inhibited cell migration and promoted cell apoptosis by blocking cell cycle at G2/M stage. Furthermore, the target dose-dependently downregulated the expression of p-EGFR and arrested the activation of downstream Akt and ERK in H1975. All these studies provide important clues for the discovery of potent noncovalent EGFRT790M/L858R inhibitors.Shandong is the most populous and highly industrialized province in eastern China, and the resultant poor air quality is a cause for widespread concern. This study combines bottom-up and top-down approaches to develop a high-resolution anthropogenic emission inventory of air pollutants for 2017. The inventory was developed based on updated emission factors and detailed activity data. The emissions of sulfur dioxide (SO2), nitrogen oxides (NOx), particulate matter with aerodynamic diameters smaller than 2.5 and 10 μm (PM2.5 and PM10, respectively), carbon monoxide (CO), volatile organic compounds (VOCs), and ammonia (NH3) were estimated to be 1387.8, 2488.6, 5281.7, 3193.0, 9250.7, 2254.7, and 1210.6 kt, respectively. Power plants were the largest contributors of SO2 and NOx emissions accounting for 43.7% and 41.9% of the total emissions, respectively. CO emissions mainly originated from industrial processes (40.1%), mobile sources (24.8%), and fossil fuel burning (21.2%). The major sources of PM10 and PM2.5 emissions were industrial processes and fugitive dust, contributing 83.